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For those transplant physicians who are not familiar with cord blood transplantation and who would like to quickly review the field, the Forum recommends the following:
The November 25, 2004 issue of the New England Journal of Medicine (Two articles on umbilical cord blood transplantation for adults and an editorial). In the Annotated Bibliography, these articles are reviewed in II. Transplantation of Adults using Cord Blood Units. Click HERE.
Information on the effectiveness of double cord blood transplants in adults, see the following article: "Transplantation of two partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy." Barker et al. Blood 2005;105:1343-1347. This article is reviewed in III. Multi-Cord Transplants. Click HERE.
For a recent comprehensive review, see "Umbilical cord blood transplantation." Rocha et al. Curr Opin Hematol. 2004;11:375-85 This article is reviewed in I. Recent Reviews (citation #2). Click HERE.
As all transplant physicians recognize, each year there are thousands of patients in need of a hematopoietic cell transplant who cannot find a suitable donor from among family members or from donor registries such as the NMDP. Can cord blood transplants, which do not require as precise an HLA match, satisfy that need for adults as well as children? Should cord blood transplants be more widely utilized? Among the alternative options is to not provide transplants even for patients with bona fide indications. The optimal way to decide is to review existing data, and the goal of this web site is to point to the availability of such information with an annotated bibliography, and to continually up-date the site as more pertinent publications become available.
Simply click on any of the topics listed below to see an annotated bibliography of recent data pertinent to that topic, or scroll down on the Annotated Bibliography page to review the entire bibliography. You may also search for any topic and/or author by clicking on the SEARCH link in the navigation menu to access our comprehensive site search feature. Among the critical topics are: Reviews, Transplantation of Adults, Multi-Cord Transplants, Cell dose, Availability and Rapidity of Obtaining of Cord Blood Units, GVHD, and HLA-matching
Please note that a link to an online abstract or full text version of each article is provided, if publicly available. Individuals with subscriptions to the journal may have online access to full text articles with a member sign-in on the journal's website. ASH members have online access to all full text articles published in Blood (initial sign-in required).
CordBloodForum.org would appreciate comments and questions.